Cryo Transmission Electron Microscope
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Key information
Overview
The Leiden Institute of Chemistry (LIC) seeks to purchase a state-of-the-art 200kV Glacios 2 cryo-TEM system for the performance of advanced cryo-transmission electron microscopy (cryo-TEM) experiments in the frame of the Oncode Accelerator project. Specifically, the instrument will be required for the following specific experiments: Sample screening and initial data collection prior to imaging on the existing Titan Krios systems in our facility for highest resolution data collection of challenging samples; High resolution single particle analysis (SPA) for the detailed analysis of Protein-Ligand and Protein-Protein interactions; Cryo-electron tomography (cryo-ET) for the analysis of cellular structures at nanometer resolution; Collection of electron diffraction data for the analysis of protein crystals. The Glacios 2 will be integrated as local Leiden University cryo-EM infrastructure within the onsite national NeCEN facility (Netherlands Centre for Electron Nanoscopy) and therefore it is of utmost importance that the instrument integrates seamlessly into the workflows of NeCEN to ensure maximum productivity and minimize instrument downtimes. NeCEN owns two ThermoFisher Titan Krios 300kV cryo-TEM microscopes.
No representations were received within 20 days after this publication, so the contract wase awarded.